2009-4

.: Дата публікації 2009-12-22 :: Переглядів: 7 :: :.

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CLINICAL PREDIСTORS OF KIDNEY ALLOGRAFT FUNCTION AND SURVIVAL
A.S. Nikonenko, A.V. Trailin, T.N. Nikonenko, T.I. Ostapenko, N.N. Polyakov, I.A. Laktionov, O.V. Pastukhov

The aim – to analyze risk factors for kidney allograft (KAG) dysfunction and reduced survival.

Materials and methods. The retrospective analysis of donor and recipient characteristics influence on the KAG function during first posttransplant year and their survival for patients transplanted in our center between 1998 and by 2008 years was conducted. For this period patients were on the 3 different modes of immunosuppressant: CsA+Aza+S (gr.1: 95 persons), CsA+MMF+S (gr.2: 33 patients), CsA+MMF+S+antibodies to the IL-2 receptor for induction (gr.3: 84 patients). The level of serum creatinine, glomerular filtration rate, proteinuria in 3, 6 and 12 months and KAG survival up to 10 years were estimated.

Results and discussion. KAG survival is determined, first of all, by its function during first year after an operation. KAG function depends on the presence of such risk factors as the use of elderly donor, presence of the delayed graft function and acute rejection after operation.

Conclusions. Thus, it was shown that KAG function and survival depend on mutual influence of antigen-dependent and antigen- independent risk factors.